Sequence annotation and liability detection
Analyze antibody formats such as IgG, scFv, VHH, and TCRs, identify FRs and CDRs, align sequences to germline references, and detect sequence-based liabilities.
PipeBio
RivendicaPipeBio is a cloud bioinformatics platform for antibody, TCR and peptide discovery, analysis, visualization and workflow automation across NGS, single-cell, Sanger and PacBio data.
Overview
PipeBio is a cloud-based bioinformatics platform for antibody, TCR, peptide, and broader biologics discovery workflows. It combines sequence analysis, data visualization, and workflow automation in a single environment for scientists and bioinformaticians.
The platform supports analysis of NGS, single-cell, Sanger, and PacBio data, plus sequence storage, metadata management, clustering, engineering, and integration with external systems through a documented REST API.
Features
Clustering and cross-sample comparison
Cluster samples by clonotype, compare experiments, identify clonal families, analyze enrichment, and explore results with cluster network plots.
Interactive visualization
Use interactive charts for amino acid frequencies, codons, genes, sequence quality, phylogeny, and other visual summaries of sequence data.
Assay data and hit picking
Associate functional assay data and metadata with sequences, then analyze properties such as ELISA results, structural liabilities, transcriptomics, and hit-picking outputs.
Antibody engineering tools
Edit sequences at nucleotide or protein level and use engineering tools to calculate protein properties, optimize degenerate codons, and analyze hydrophobicity.
REST API integration and automation
Configure REST API connections and workflows to upload and download data, integrate ELN or LIMS systems, and automate pipelines with internal tools.
Use Cases
Antibody discovery pipelines
Start from large antibody repertoires, hybridoma sequencing, or biopanning experiments and use standardized workflows to move toward a candidate hit list.
Sequence database management
Store sequence records in a central database, attach metadata such as target specificity or binding affinity, and compare new results against in-house or public sequences.
Clonotype and sample comparison
Analyze paired chains, clonotypes, clonal families, and enrichment across experiments to understand repertoire changes over time.
Assay-linked prioritization
Combine sequence data with functional assay results to support hit picking and prioritize candidates for follow-up analysis.
Workflow automation and integration
Build automated analysis pipelines that connect PipeBio with ELN, LIMS, internal tools, or custom code through the REST API.
Pros and Cons
Pros
- Combines sequence analysis, visualization, storage, and workflow automation in one cloud platform.
- Supports multiple sequence data types, including NGS, single-cell, Sanger, and PacBio.
- Includes tools for annotation, clustering, hit picking, and antibody engineering.
- Offers REST API-based integration with ELN, LIMS, internal tools, and lab instruments.
- Provides configurable workflows and standard reports for repeatable analysis.
Cons
- Pricing is not published on the site, and commercial use requires contacting the team.
- Some integrations and customizations are described as available through professional services or custom development rather than fully self-serve.
FAQ
How is PipeBio priced and how many users can use it?
PipeBio is offered as software as a service with an annual subscription fee. The pricing page says you can contact the team for more information, and the FAQ notes that commercial plans start from 5 named users while enterprise plans support an unlimited number of users.
Can multiple people on a team use PipeBio?
The platform is designed for cloud access, so team members can log in from anywhere and work on shared sequence or assay data. The pricing FAQ says additional team members can be added to an organization.
Can PipeBio be customized for a specific workflow?
PipeBio supports configurable end-to-end workflows. The workflow page says users can combine tools, set parameters, automatically create reports, and use the API for programmatic upload, export, and user management.
What integrations does PipeBio support?
Yes. The platform pages describe REST API-based integration with ELN, LIMS, internal tools, and lab instruments. The workflow page also mentions support for documented API examples and integration with systems such as Benchling.
Who is PipeBio for?
The source describes PipeBio as a cloud-based platform for antibody, TCR, VHH, scFv, short peptide, and sequence analysis. It is best suited to biologics discovery teams that need sequence analysis, annotation, clustering, visualization, and workflow automation.
Quick Facts
- Category
- Bioinformatics platform
- Primary users
- Scientists and bioinformaticians working on biologics discovery
- Deployment
- Cloud-based SaaS
- Data types
- NGS, single-cell, Sanger, and PacBio sequence data
- Integrations
- REST API, ELN, LIMS, internal tools, lab instruments
- Pricing
- Annual subscription with contact-sales pricing