Cradle

Cradle is a protein engineering AI platform for scientists. It helps biopharma and industrial bio teams generate protein candidates, optimize multiple properties, and learn from their own experimental data.

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What Cradle is

Cradle is a protein engineering AI platform for scientists. It is designed to help teams generate protein candidates and improve their properties using data from their own experiments.

The site positions Cradle as a workflow for round-based protein design and optimization rather than a one-off generator. Teams can use it to manage candidate generation, upload experimental results, and train models on data from multiple rounds to guide the next design cycle.

The platform is shown for biopharma and industrial bio programs, with examples spanning antibodies, enzymes, peptides, and vaccines. The company also emphasizes private workspaces, owned sequence IP, and annual software licensing instead of royalty or milestone-based deals.

Core capabilities

AI-guided candidate generation

Generate protein candidates and iterate on them using your organization’s experimental data, so model output is informed by results from your own program.

Round-based project tracking

Track round status from candidate generation through uploading experimental results, with reports and data management in the workflow.

Multi-property optimization

Set objectives across multiple properties such as affinity, specificity, activity, stability, and expression to optimize trade-offs together.

Broad protein coverage

Use the platform for therapeutics, agricultural solutions, food ingredients, and other protein programs where measurable properties can be optimized.

UI and API workflows

Run Cradle through the user interface or the API, with simple defaults for some teams and more advanced control for users with in-house expertise.

Enterprise licensing model

Use private workspaces, full ownership of sequence IP, and integrated support for organization-level deployment.

Practical ways to use Cradle

Antibody engineering
Use Cradle to design and optimize antibody sequences, including affinity maturation, developability, and liability reduction across CDRs or framework regions.
Non-antibody protein optimization
Apply the platform to enzyme, peptide, or vaccine programs where you need to improve measurable properties such as stability, efficacy, or expression.
Data-driven iteration
Feed assay results, screening data, and other experimental outputs into the platform to guide another design round and improve the next set of candidates.
Multi-objective design
Run programs that need multiple objectives optimized together, such as binding, specificity, activity, and stability, instead of trading them off manually.
Team workflows
Use the UI for guided workflows or the API for more controlled program execution across teams with varying computational experience.

Pros and Cons

Pros

Built around experimental data from the customer’s own program, which helps tie design to observed results.
Supports multi-property optimization, not just single-metric screening.
Covers several protein program types, including antibodies, enzymes, peptides, and vaccines.
Offers both UI and API access, which may suit different team workflows.
Uses private workspaces and states that sequence IP remains owned by the customer.

Cons

The public pricing page is not available, so buyers cannot compare published prices or plan limits.
The source materials do not show a detailed list of integrations or supported data connectors.
Some workflow details are described at a high level rather than with step-by-step product documentation.

FAQ

What does Cradle do?

Cradle is a protein engineering AI platform built for scientists. It is used to generate protein candidates and improve properties such as binding, specificity, activity, stability, and expression using experimental data from the user’s own program.

Who is Cradle for?

The source materials show Cradle positioned for biopharma and industrial bio teams, with examples across antibodies, enzymes, peptides, and vaccines.

How do teams use the platform?

Cradle’s site says workflows can run through its user interface or via API, and that teams can start with simple defaults or more advanced design requirements.

How is Cradle licensed?

The licensing page says Cradle offers annual software licenses rather than royalty or milestone-based deals. It lists Standard, Enterprise, and Academic licensing options.

Is pricing available on the website?

The source does not list public pricing on the pricing page; it shows a page-not-found message and directs visitors back to the home page or sales contact flows.

Quick Facts

Category: AI protein engineering software
Primary users: Scientists and R&D teams in biopharma and industrial bio
Supported program types: Antibodies, enzymes, peptides, vaccines, and other measurable protein programs
Access model: Web platform with UI and API workflows
Licensing: Annual software license
Website: cradle.bio